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Data

Statistical Summary of 2P2IDB Interfaces (v1.0 archive 2013)

The table below shows "means" and "standard deviations" of interfaces parameters calculated for the two classes of druggable complexes in 2P2IDB. Values for non-redundant representative datasets of Hetero- and Homo- dimeric complexes collected through the Dockground server are indicated as comparison for both classes.

 

Interface Properties 2P2IDB
Heterodimers
Homodimers
Class I Class II Class I Class II Class I Class II
Nb of complexes 7 7 189 336 331 1442
BASA (Ų) 1384.7 ±516.1 1793.3 ±591.6 2149.2 ±1017.6 2769.3 ±1411.4 2307.2 ±1503.1 3042.1 ±1823.1
Gap Volume (Å3) 2282.8 ±1351.5 5085.2 ±2199.7 3906.7 ±1745.2 6670.3 ±3128.1 3780.8 ±1775.1 6969.9 ±3716.9
Non-bonded contacts 74.4 ±27.5 94.4 ±39.9 114.5 ±57.2 151.5 ±84.1 114.2 ±80.4 164.6 ±114.1
Total Nb of segments 4.1 ±1.1 8.1 ±1.8 6.1 ±2.7 10.8 ±3.8 3.9 ±1.1 10.7 ±4.6
Nb of hydrogen bonds 2.4 ±1.3 3.3 ±2.5 4.8 ±3.7 6.7 ±5.0 4.6 ±5.4 7.2 ±6.3
Nb of salt bridges 0.6 ±0.8 0.6 ±0.8 1.8 ±1.8 2.0 ±1.8 1.4 ±1.8 2.0 ±2.5
Nb of disulfide bonds 0.0 ±0.0 0.0 ±0.0 0.03 ±0.2 0.03 ±0.2 0.01 ±0.1 0.01 ±0.1
% Charged residues 20.9 ±8.8 28.9 ±11.5 28.7 ±13.2 26.6 ±11.7 26.6 ± 12.8 25.6 ±11.5